|
KMID : 0613820120220081132
|
|
Journal of Life Science
2012 Volume.22 No. 8 p.1132 ~ p.1136
|
|
|
Regulation of Endoplasmic Reticulum Stress Response by the Immobilization Stress
|
|
Kwon Ki-Sang
Kwon Young-Sook
Kim Seung-Whan
Kim Dong-Woon
Kwon O-Yu
|
|
|
Abstract
|
|
|
|
Many kind of cell stresses induce gene expression of unfolded protein response (UPR)-associated factors. This study demonstrated that up- and down-regulation of gene expression of endoplasmic reticulum (ER) stress chaperones and ER stress sensors was induced by immobilization stress in the rat organs (adrenal gland, liver, lung, muscle). However, no statistically significant regulation was detected in the others (heart, spleen, thymus, kidney, testis). The results are the first to show that immobilization stress induces UPR associated gene expression, will help to explain immobilization stress-associated ER stress.
|
|
|
KEYWORD
|
|
|
Immobilization stress, endoplasmic reticulum (ER) stress, ER chaperone, ER stress sensor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|